Browsing by Author "Askin Uzel, Ruhan"

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Citation - WoS: 4
Citation - Scopus: 6
A novel method for food particle production using subcritical water extraction: Ganoderma mushroom as a case example
(ELSEVIER SCIENCE BV, 2016) Ruhan Askin Uzel; Unal Riza Yaman; Uzel, Ruhan Askin; Askin Uzel, Ruhan; Yaman, Unal Riza
In recent years supercritical fluid-based technologies have been used for the production of food particles as well as the extraction. These methods are used in particle generation as well as extraction due to properties of solvent such as having good dissolving and diffusing power moderable conditions capability to produce particles with a regular particle size distribution of the solvent and being environmentally friendly. Recently three different techniques named rapid expansion of supercritical fluid(RESS) supercritical anti solvent application (SAS) and particle formation with gas-saturated solvent (PGSS) are used for particle generation. In this study a novel system capable of doing subcritical water extraction and particle formation was briefly introduced. The system was based on first hydrothermal extraction of target compound then transition of saturated extract solution into fine particles at underfiow in hot air assistance. Ganoderma lucidum mushroom was used as working material to investigate process parameters. Also extract composition and structure were identified. (C) 2016 Elsevier B.V. All rights reserved.
Citation - WoS: 5
Citation - Scopus: 5
Supercritical CO2 extraction of an immunosuppressant produced by solid-state fermentation
(ELSEVIER SCI LTD, 2018) Ilknur Alpak; Ruhan Askin Uzel; Sayit Sargin; Ozlem Yesil-Celiktas; Uzel, Ruhan Askin; Yesil-Celiktas, Ozlem; Sargin, Sayit; Askin Uzel, Ruhan; Alpak, Ilknur
Mycophenolic acid (MPA) is a secondary metabolite of Penicillium species with diverse biological properties and has clinical applications mainly as an immunosuppressive agent. Production of MPA was carried out using Penicillium brevicompactum (DSM 2215) by solid-state fermentation (SSF). Six different carbon sources (wheat bran rice husk rice bran potato peel and rice husk - rice bran rice bran-potato peel mixture) were examined by SSF in order to obtain the highest yield of mycophenolic acid. Rice bran-potato peel mixture was determined as the best solid substrate and used in scale up studies which was applied in the tray bioreactor. Supercritical CO2 and soxhlet extractions were analyzed for the recovery of MPA from the fermentation broth. The highest recovery (0.47 g MPA/100 g substrate) was obtained by supercritical CO2 at 30 MPa 50 degrees C at a CO2 flow rate of 15 g/min with 10% ethanol as co-solvent for 3 h. The results obtained by the scale-up in bioreactor and optimization of supercritical CO2 entrained with ethanol can provide basis for the production of the immunosuppresant compound on industrial scale.