Browsing by Author "Kanbak, Gungor"

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Citation - WoS: 37
Citation - Scopus: 36
Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor- Coprinus comatus- and Lenzites betulina isolates in streptozotocin-induced diabetic rats
(TAYLOR & FRANCIS INC, 2009) Mustafa Yamac; Melih Zeytinoglu; Gungor Kanbak; Gokhan Bayramoglu; Hakan Senturk; Senturk, Hakan; Kanbak, Gungor; Yamac, Mustafa; Bayramoglu, Gokhan; Zeytinoglu, Melih
The objective of this study was to investigate the hypoglycemic activity of crude exopolysaccharides (EPS) produced by three mushroom isolates in streptozotocin-induced diabetic rats. The three experimental groups were fed EPS of Cerrena unicolor (Bull.) Murrill (Polyporaceae) Coprinus comatus (O.F. Mull.) Pers. (Agaricaceae) and Lenzites betulina (L.) Fr. (Polyporaceae) for 7 days. The serum glucose levels significantly decreased after oral administration of EPS by 61.23% with Cerrena unicolor 42.78% with Coprinus comatus and 42.08% with Lenzites betulina. According to histological observations based on staining in pancreatic tissues Langerhans islet areas and cell numbers of diabetic animals increased in response to EPS treatment. In conclusion our findings clearly suggest that exopolysaccharides produced by three mushroom isolates decreased blood glucose levels in STZ-induced diabetic rats. Therefore the studied mushroom exopolysaccharides might be developed as potential oral hypoglycemic agents in the control of diabetes mellitus. This is the first attempted in vivo study using exopolysaccharides of local mushroom isolates for medicinal purpose in Turkey.
Citation - WoS: 32
Citation - Scopus: 35
Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats
(Mary Ann Liebert, Inc, 2008) Mustafa Yamaç; Güngör Kanbak; Melih Zeytinoǧlu; Gökhan Bayramoǧlu; Hakan Şenturk; Mustafa Uyanoǧlu; Senturk, Hakan; Uyanoglu, Mustafa; Kanbak, Gungor; Yamac, Mustafa; Bayramoglu, Gokhan; Zeytinoglu, Melih
This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study diabetic rats were treated with EPS at doses of 50-150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal STZ-induced diabetic and EPS-treated diabetic rats. Following oral administration of EPS dosages for 7 days the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS at the dose of 150 mg/kg exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P < .05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans. © 2008 Mary Ann Liebert Inc. © 2009 Elsevier B.V. All rights reserved., MEDLINE® is the source for the MeSH terms of this document.
Citation - WoS: 23
Citation - Scopus: 34
Pancreas Protective Effect of Button Mushroom Agaricus bisporus (JE Lange) Imbach (Agaricomycetidae) Extract on Rats with Streptozotocin-Induced Dia betes
(BEGELL HOUSE INC, 2010) Mustafa Yamac; Gungor Kanbak; Melih Zeytinoglu; Hakan Senturk; Gokhan Bayramoglu; Ali Dokumacioglu; Leo Van Griensven; Van Griensven, Leo; Senturk, Hakan; Kanbak, Gungor; Yamac, Mustafa; Bayramoglu, Gokhan; Dokumacioglu, Ali; Zeytinoglu, Melih
In the present study we describe the effects of hot water extract of the culinary-medicinal button mushroom Agaricus bisporus on the symptoms of streptozotocin-induced diabetes in Sprague Dawley rats. A. bisporus extract at the doses of 0 100 200 and 400 mg/kg body weight (bw) per day were orally applied to streptozotocin-induced diabetic rats for a period of 7 days after the onset of the diabetes. Food and water intake and body weight were recorded daily. Upon sacrifice histological studies were performed on pancreas tissues and biochemical parameters such as glucose insulin superoxide dismutase malondialdehyde and catalase were measured of all experimental groups. The serum glucose levels significantly decreased after oral administration at the dose of 400 mg/kg bw per day by 29.68% with A. bisporus extract. Furthermore the serum insulin levels in the streptozotocin-induced diabetic rats were increased to 78.50% at the extract dose of 400 mg/kg bw per day. Also catalase activities and malondialdehyde levels decreased to values slightly above the normal animal control. The most obvious and surprising change was however the increase in cellularity of the Langerhans islets of the pancreas and their apparent repopulation with beta cells. We conclude that the oral application of high doses of A. bisporus extract may result in decreased severity of streptozotocin-induced diabetes in rat.