Browsing by Author "Kitis, Omer"

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Citation - WoS: 5
Citation - Scopus: 4
Computer based classification of MR scans in first time applicant Alzheimer patients
(Bentham Science Publ Ltd, 2012) Fatma Eksi Polat; Selçuk Orhan Demirel; Ömer Kitiş; Fatma Şimşek; Damla İşman Haznedaroǧlu; Kerry Lee Coburn; Emre Kumral; Ali Saffet Gönül; Simsek, Fatma; Kitis, Omer; Demirel, Selcuk Orhan; Gonul, Ali Saffet; Haznedaroglu, Damla Isman; Coburn, Kerry; Polat, Fatma
In this study we aimed to classify MR images for recognizing Alzheimer Disease (AD) in a group of patients who were recently diagnosed by clinical history and neuropsychiatric exams by using non-biased machine-learning techniques. T1 weighted MRI scans of 31 patients with probable AD and 31 age- and gender-matched cognitively normal elderly were analyzed with voxel-based morphometry and classified by support vector machine (SVM) a machine learning technique. SVM could differentiate patients from controls with accuracy of 74 % (sensitivity: 70 % and specificity: 77 %) when the whole brain was included the analyses. The classification accuracy was increased to 79 % (sensitivity: 65 % and specificity: 93 %) when the analyses restricted to hippocampus. Our results showed that SVM is a promising tool for diagnosis of AD but needed to be improved. © 2012 Bentham Science Publishers. © 2013 Elsevier B.V. All rights reserved., MEDLINE® is the source for the MeSH terms of this document.
Citation - WoS: 3
Citation - Scopus: 1
The effects of the duration of formal education on adult brain: A voxel-based morphometry - (diffeomorphic anatomical registration using exponentiated lie algebra) DARTEL study
(Kure Iletisim Grubu A S, 2009) Ali Saffet Gönül; Orhan Demirel; Ömer Kitiş; Mehmet Çaǧdaş Eker; Özlem Donat Eker; Erol Ozan; Ozan, Erol; Demirel, Orhan; Eker, Cagdas; Kitis, Omer; Gonul, Ali Saffet; Eker, Ozlem Donat
Objective: Recent studies neuroimaging showed that continues environmental stimuli can induce structural changes in the brain. Compared to later life during formal education in school and university, human brain is not only continuously stimulated with new information but also retrieves the already learned information and extends it with the new one. In this study we explored the effects of this extensive learning process on brain structure by using voxel-based morphometry (VBM) -DARTEL method. Method: Forty-seven healthy adults were included in this study. After screened carefully by SCID-NP all subjects were scanned by Siemens 1.5T Magnetic Resonance Imaging machine. T1 weighted images were analyzed by SPM 5 (Statistical Parametric Mapping software) via VBM protocol. Results: Our VBM results showed that the right anterior hippocampus gray matter volume was correlated with the duration of formal education. We also observed that education showed positive correlations with Brodmann (BA) 18 in the occipital lobes and with the right cerebellum. However the right parietal cortex (BA 7) and the right middle frontal cortex (BA 8) showed negative correlations with education. Conclusion: Our study showed that there is an association between the duration of formal education and the gray matter volume of brain regions related to the detection of novel stimuli semantic and spatial memory and visual system which might be related to extensive learning process during formal education years. © 2009 Elsevier B.V. All rights reserved.