Browsing by Author "Taylan, Enes"

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Citation - WoS: 4
Citation - Scopus: 5
The Impact of Carbon Dioxide Pneumoperitoneum on Ovarian Ischemia-Reperfusion Injury during Laparoscopic Surgery: A Preliminary Study
(ELSEVIER SCIENCE INC, 2018) Ali Akdemir; Enes Taylan; Cagdas Sahin; Banu Ozgurel; Ayfer Karlitepe; Osman Zekioglu; Gulinnaz Ercan; Taylan, Enes; Sahin, Cagdas; Karlitepe, Ayfer; Ercan, Gulinnaz; Akdemir, Ali; Zekioglu, Osman; Ozgurel, Banu
Study Objective: To investigate whether carbon dioxide pneumoperitoneum causes ischemia-reperfusion injury to the ovaries during laparoscopic surgery. Design: A prospective controlled clinical study (Canadian Task Force classification II-1). Setting: A tertiary academic center. Patients: Premenopausal women who underwent hysterectomy with bilateral salpingo-oophorectomy (HSO) via open abdominal and laparoscopic approaches between 2014 and 2015. Interventions: In both surgical approaches unilateral oophorectomy was performed immediately after abdominal entry and the remaining contralateral ovary was excised at the end of the hysterectomy in order to compare the effect of these surgical procedures on ovarian tissue. Additionally plasma samples were collected at the following time points: (1) before abdominal entry (2) at the end of hysterectomy and (3) before contralateral oophorectomy. Plasma samples were assessed for biochemical oxidative stress markers malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Ovarian tissue samples were assessed for MDA and further evaluated for ischemia-reperfusion injury using a histologic scoring method. Measurements and Main Results: Twenty premenopausal women undergoing HSO via open abdominal surgery (n = 10) and laparoscopy (n = 10) were included. Baseline characteristics (age body mass index parity and gravida) and operative data (operative time estimated blood loss and intraoperative complication) were similar between groups. Perioperative plasma MDA levels histologic scores and tissue oxidative stress markers did not show a significant difference in either group or between groups. However plasma 8-OHdG levels were significantly different when the second sample in the abdominal HSO group was compared with the first sample in the abdominal HSO group and the third sample in the laparoscopic HSO group (p =.012 and .001 respectively). Conclusion: Carbon dioxide pneumoperitoneum does not cause ischemia-reperfusion injury in the human ovaries at clinically safe levels of intra-abdominal pressure. (C) 2017 AAGL. All rights reserved.
Citation - WoS: 20
Citation - Scopus: 23
The impact of salpingectomy and single-dose systemic methotrexate treatments on ovarian reserve in ectopic pregnancy
(ELSEVIER SCIENCE BV, 2016) Cagdas Sahin; Enes Taylan; Ali Akdemir; Banu Ozgurel; Dilek Taskiran; Ahmet M. Ergenoglu; Akdemir, Ali; Ergenoglu, Ahmet M.; Ozgurel, Banu; Taylan, Enes; Taskiran, Dilek; Sahin, Cagdas
Objective: To investigate the effects of salpingectomy and methotrexate treatments on ovarian reserve in ectopic pregnancy. Study design: In this prospective study a total of 131 patients with ectopic pregnancy were divided into 3 groups of methotrexate (MTX) only (Group-1 n: 55) salpingectomy only (Group-2 n: 61) and salpingectomy following MTX (Group-3 n: 15). Pretreatment and post-treatment anti-Mullerian hormone (AMH) levels were evaluated. Results: Significant differences in AMH levels were detected between group 1 and group 2 (2.52 +/- 1.28 vs. 1.96 +/- 1.66 p = 0.043) and group 1 and group 3 (2.52 +/- 1.28 vs. 1.77 +/- 0.76 p = 0.035) at one month postoperative. However these differences disappeared at the 3rd postoperative month. When AMH levels were compared within the same group postoperative one month AMH levels were significantly lower than the preoperative AMH levels only in group 3 (p = 0.03). However this difference also disappeared at the 3rd postoperative month. Conclusion: Systemic single-dose methotrexate treatment unilateral salpingectomy and salpingectomy following methotrexate administration in ectopic pregnancy were reassuring based on pretreatment and post-treatment AMH levels. Current medical and surgical treatment approaches do not have an obvious negative effect on ovarian reserve. (C) 2016 Elsevier Ireland Ltd. All rights reserved.