Browsing by Author "Uyanoglu, Mustafa"

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    Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats
    (Mary Ann Liebert, Inc, 2008) Mustafa Yamaç; Güngör Kanbak; Melih Zeytinoǧlu; Gökhan Bayramoǧlu; Hakan Şenturk; Mustafa Uyanoǧlu; Senturk, Hakan; Uyanoglu, Mustafa; Kanbak, Gungor; Yamac, Mustafa; Bayramoglu, Gokhan; Zeytinoglu, Melih
    This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study diabetic rats were treated with EPS at doses of 50-150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal STZ-induced diabetic and EPS-treated diabetic rats. Following oral administration of EPS dosages for 7 days the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS at the dose of 150 mg/kg exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P < .05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans. © 2008 Mary Ann Liebert Inc. © 2009 Elsevier B.V. All rights reserved., MEDLINE® is the source for the MeSH terms of this document.