Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method
| dc.contributor.author | Neslihan Avcu | |
| dc.contributor.author | Cuneyt Guzelis | |
| dc.contributor.author | Guzelis, Cuneyt | |
| dc.contributor.author | Avcu, Neslihan | |
| dc.date | DEC | |
| dc.date.accessioned | 2025-10-06T16:21:13Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Most of the biological systems including gene regulatory networks can be described well by ordinary differential equation models with rational non-linearities. These models are derived either based on the reaction kinetics or by curve fitting to experimental data. This study demonstrates the applicability of the root-locus-based bifurcation analysis method for studying the complex dynamics of such models. The effectiveness of the bifurcation analysis in determining the exact parameter regions in each of which the system shows a certain dynamical behaviour such as bistability oscillation and asymptotically equilibrium dynamics is shown by considering two mostly studied gene regulatory networks namely Gardner's genetic toggle switch and p53 gene network possessing two-phase (mono-stable/oscillation) dynamics. | |
| dc.identifier.doi | 10.1049/iet-syb.2019.0043 | |
| dc.identifier.issn | 1751-8849 | |
| dc.identifier.issn | 1751-8857 | |
| dc.identifier.scopus | 2-s2.0-85075723626 | |
| dc.identifier.uri | http://dx.doi.org/10.1049/iet-syb.2019.0043 | |
| dc.identifier.uri | https://gcris.yasar.edu.tr/handle/123456789/6768 | |
| dc.identifier.uri | https://doi.org/10.1049/iet-syb.2019.0043 | |
| dc.language.iso | English | |
| dc.publisher | INST ENGINEERING TECHNOLOGY-IET | |
| dc.relation.ispartof | IET Systems Biology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | IET SYSTEMS BIOLOGY | |
| dc.subject | oscillations, curve fitting, differential equations, bifurcation, genetics, nonlinear dynamical systems, nonlinearities, reaction kinetics, root-locus-based bifurcation analysis method, complex dynamics, exact parameter regions, dynamical behaviour, equilibrium dynamics, studied gene regulatory networks, p53 gene network, bistable dynamics, oscillatory dynamics, biological networks, root-locus method, biological systems, ordinary differential equation models | |
| dc.subject | 1ST HARMONIC-ANALYSIS, 2-PHASE DYNAMICS, CONTROL-SYSTEMS, P53, MULTISTABILITY | |
| dc.subject | Exact Parameter Regions | |
| dc.subject | P53 Gene Network | |
| dc.subject | Oscillatory Dynamics | |
| dc.subject | Ordinary Differential Equation Models | |
| dc.subject | Root-Locus Method | |
| dc.subject | Bistable Dynamics | |
| dc.subject | Equilibrium Dynamics | |
| dc.subject | Biological Systems | |
| dc.subject | Nonlinear Dynamical Systems | |
| dc.subject | Differential Equations | |
| dc.subject | Biological Networks | |
| dc.subject | Bifurcation | |
| dc.subject | Genetics | |
| dc.subject | Reaction Kinetics | |
| dc.subject | Dynamical Behaviour | |
| dc.subject | Studied Gene Regulatory Networks | |
| dc.subject | Nonlinearities | |
| dc.subject | Root-Locus-Based Bifurcation Analysis Method | |
| dc.subject | Curve Fitting | |
| dc.subject | Oscillations | |
| dc.subject | Complex Dynamics | |
| dc.title | Bifurcation analysis of bistable and oscillatory dynamics in biological networks using the root-locus method | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| gdc.author.scopusid | 55937768800 | |
| gdc.author.scopusid | 24723481800 | |
| gdc.author.wosid | Avcu, Neslihan/Q-1786-2019 | |
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| gdc.description.department | ||
| gdc.description.departmenttemp | [Avcu, Neslihan] Dokuz Eylul Univ, Dept Elect Elect Engn, TR-35390 Izmir, Turkey; [Guzelis, Cuneyt] Yasar Univ, Dept Elect Elect Engn, TR-35100 Izmir, Turkey | |
| gdc.description.endpage | 345 | |
| gdc.description.issue | 6 | |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| gdc.description.startpage | 333 | |
| gdc.description.volume | 13 | |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.identifier.openalex | W2969349722 | |
| gdc.identifier.pmid | 31778130 | |
| gdc.identifier.wos | WOS:000499465900007 | |
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| gdc.oaire.keywords | Systems Biology | |
| gdc.oaire.keywords | Gene Regulatory Networks | |
| gdc.oaire.keywords | Tumor Suppressor Protein p53 | |
| gdc.oaire.keywords | Models, Biological | |
| gdc.oaire.popularity | 6.9970616E-9 | |
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| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
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| gdc.virtual.author | Güzeliş, Cüneyt | |
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| oaire.citation.endPage | 345 | |
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| publicationissue.issueNumber | 6 | |
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