Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats

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dc.contributor.author Mustafa Yamaç
dc.contributor.author Güngör Kanbak
dc.contributor.author Melih Zeytinoǧlu
dc.contributor.author Gökhan Bayramoǧlu
dc.contributor.author Hakan Şenturk
dc.contributor.author Mustafa Uyanoǧlu
dc.contributor.author Senturk, Hakan
dc.contributor.author Uyanoglu, Mustafa
dc.contributor.author Kanbak, Gungor
dc.contributor.author Yamac, Mustafa
dc.contributor.author Bayramoglu, Gokhan
dc.contributor.author Zeytinoglu, Melih
dc.date.accessioned 2025-10-06T17:53:15Z
dc.date.issued 2008
dc.description.abstract This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study diabetic rats were treated with EPS at doses of 50-150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal STZ-induced diabetic and EPS-treated diabetic rats. Following oral administration of EPS dosages for 7 days the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS at the dose of 150 mg/kg exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P < .05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans. © 2008 Mary Ann Liebert Inc. © 2009 Elsevier B.V. All rights reserved., MEDLINE® is the source for the MeSH terms of this document.
dc.description.sponsorship Eskisehir Osmangazi University Research Foundation [200619016]; Scientific Research and Application Centre (FBAM); Department of Biology, Eskisehir Osmangazi University
dc.description.sponsorship This study was supported by the Eskisehir Osmangazi University Research Foundation (project number 200619016), the Scientific Research and Application Centre (FBAM), and the Department of Biology, Eskisehir Osmangazi University. The authors extend their thanks to Burcu Altinay, Dr. Onur Koyuncu, and O. Koray Yaylaci for their technical support and to Dr. O. Serhat Irez for revising the manuscript.
dc.identifier.doi 10.1089/jmf.2007.0551
dc.identifier.issn 15577600, 1096620X
dc.identifier.issn 1096-620X
dc.identifier.issn 1557-7600
dc.identifier.scopus 2-s2.0-52149121661
dc.identifier.uri https://www.scopus.com/inward/record.uri?eid=2-s2.0-52149121661&doi=10.1089%2Fjmf.2007.0551&partnerID=40&md5=f030344c05f8f347f44483b90a975b2a
dc.identifier.uri https://gcris.yasar.edu.tr/handle/123456789/10353
dc.identifier.uri https://doi.org/10.1089/jmf.2007.0551
dc.language.iso English
dc.publisher Mary Ann Liebert, Inc
dc.relation.ispartof Journal of Medicinal Food
dc.rights info:eu-repo/semantics/closedAccess
dc.source Journal of Medicinal Food
dc.subject Exopolysaccharide, Hypoglycemic Effect, Lentinus Strigosus, Glucose, Insulin, Blood Glucose, Hypoglycemic Agents, Insulin, Polysaccharides, Streptozocin, Exopolysaccharide, Glucose, Insulin, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Article, Comparative Study, Controlled Study, Dose Response, Female, Glucose Blood Level, Hypoglycemia, Insulin Blood Level, Lentinus Strigosus, Medicinal Plant, Nonhuman, Priority Journal, Rat, Streptozocin Diabetes, Animals, Blood Glucose, Body Weight, Diabetes Mellitus Experimental, Eating, Hypoglycemic Agents, Insulin, Islets Of Langerhans, Lentinula, Phytotherapy, Polysaccharides, Rats, Streptozocin, Lentinus Strigosus, Polyporaceae, Rattus
dc.subject exopolysaccharide, glucose, insulin, animal cell, animal experiment, animal model, animal tissue, article, comparative study, controlled study, dose response, female, glucose blood level, hypoglycemia, insulin blood level, lentinus strigosus, medicinal plant, nonhuman, priority journal, rat, streptozocin diabetes, Animals, Blood Glucose, Body Weight, Diabetes Mellitus Experimental, Eating, Hypoglycemic Agents, Insulin, Islets of Langerhans, Lentinula, Phytotherapy, Polysaccharides, Rats, Streptozocin, Lentinus strigosus, Polyporaceae, Rattus
dc.subject Exopolysaccharide
dc.subject Hypoglycemic Effect
dc.subject Lentinus Strigosus
dc.title Hypoglycemic effect of Lentinus strigosus (Schwein.) Fr. crude exopolysaccharide in streptozotocin-induced diabetic rats
dc.type Article
dspace.entity.type Publication
gdc.author.id Yamaç, Mustafa/0000-0002-7262-0036
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gdc.author.wosid Yamaç, Mustafa/AAF-4420-2019
gdc.author.wosid Şentürk, Hakan/F-3092-2011
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gdc.description.department
gdc.description.departmenttemp [Yamac, Mustafa; Bayramoglu, Gokhan; Senturk, Hakan; Uyanoglu, Mustafa] Eskisehir Osmangazi Univ, Dept Biol, Fac Arts & Sci, TR-26480 Meselik, Eskisehir, Turkey; [Yamac, Mustafa; Bayramoglu, Gokhan; Senturk, Hakan; Uyanoglu, Mustafa] Eskisehir Osmangazi Univ, Dept Biochem, Fac Med, TR-26480 Meselik, Eskisehir, Turkey; [Zeytinoglu, Melih] Yasar Univ, Vocat Sch, Izmir, Turkey
gdc.description.endpage 517
gdc.description.issue 3
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
gdc.description.startpage 513
gdc.description.volume 11
gdc.description.woscitationindex Science Citation Index Expanded
gdc.identifier.openalex W1985964691
gdc.identifier.pmid 18800900
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gdc.oaire.keywords Blood Glucose
gdc.oaire.keywords Body Weight
gdc.oaire.keywords Lentinula
gdc.oaire.keywords Streptozocin
gdc.oaire.keywords Diabetes Mellitus, Experimental
gdc.oaire.keywords Rats
gdc.oaire.keywords Eating
gdc.oaire.keywords Islets of Langerhans
gdc.oaire.keywords Polysaccharides
gdc.oaire.keywords Animals
gdc.oaire.keywords Hypoglycemic Agents
gdc.oaire.keywords Insulin
gdc.oaire.keywords Phytotherapy
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gdc.opencitations.count 30
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gdc.scopus.citedcount 35
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oaire.citation.endPage 517
oaire.citation.startPage 513
person.identifier.scopus-author-id Yamaç- Mustafa (11339801900), Kanbak- Güngör (6603920397), Zeytinoǧlu- Melih (8719661200), Bayramoǧlu- Gökhan (23468727500), Şenturk- Hakan (35320276300), Uyanoǧlu- Mustafa (8513122300)
publicationissue.issueNumber 3
publicationvolume.volumeNumber 11
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