Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor- Coprinus comatus- and Lenzites betulina isolates in streptozotocin-induced diabetic rats
| dc.contributor.author | Mustafa Yamac | |
| dc.contributor.author | Melih Zeytinoglu | |
| dc.contributor.author | Gungor Kanbak | |
| dc.contributor.author | Gokhan Bayramoglu | |
| dc.contributor.author | Hakan Senturk | |
| dc.contributor.author | Senturk, Hakan | |
| dc.contributor.author | Kanbak, Gungor | |
| dc.contributor.author | Yamac, Mustafa | |
| dc.contributor.author | Bayramoglu, Gokhan | |
| dc.contributor.author | Zeytinoglu, Melih | |
| dc.date.accessioned | 2025-10-06T16:22:36Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | The objective of this study was to investigate the hypoglycemic activity of crude exopolysaccharides (EPS) produced by three mushroom isolates in streptozotocin-induced diabetic rats. The three experimental groups were fed EPS of Cerrena unicolor (Bull.) Murrill (Polyporaceae) Coprinus comatus (O.F. Mull.) Pers. (Agaricaceae) and Lenzites betulina (L.) Fr. (Polyporaceae) for 7 days. The serum glucose levels significantly decreased after oral administration of EPS by 61.23% with Cerrena unicolor 42.78% with Coprinus comatus and 42.08% with Lenzites betulina. According to histological observations based on staining in pancreatic tissues Langerhans islet areas and cell numbers of diabetic animals increased in response to EPS treatment. In conclusion our findings clearly suggest that exopolysaccharides produced by three mushroom isolates decreased blood glucose levels in STZ-induced diabetic rats. Therefore the studied mushroom exopolysaccharides might be developed as potential oral hypoglycemic agents in the control of diabetes mellitus. This is the first attempted in vivo study using exopolysaccharides of local mushroom isolates for medicinal purpose in Turkey. | |
| dc.description.sponsorship | Eskisehir Osmangazi University Research Foundation [200619016]; Scientific Research and Application Center (FBAM); Biology Department of Eskisehir Osmangazi University | |
| dc.description.sponsorship | This is study was supported by the Eskisehir Osmangazi University Research Foundation (Project no: 200619016), Scientific Research and Application Center (FBAM) and Biology Department of Eskisehir Osmangazi University. The authors wish to thank Dr. Berna Yazici for statistical analysis and Burcu Altinay, Dr. Onur Koyuncu, Dr. M. Halil Solak, and Mr. O. Koray Yaylaci for their technical support. | |
| dc.description.sponsorship | Eskisehir Osmangazi University; Eskişehir Osmangazi University Research Foundation, (200619016); FBAM; Scientific Research and Application Center | |
| dc.identifier.doi | 10.1080/13880200802436950 | |
| dc.identifier.issn | 1388-0209 | |
| dc.identifier.issn | 1744-5116 | |
| dc.identifier.scopus | 2-s2.0-70749160094 | |
| dc.identifier.uri | http://dx.doi.org/10.1080/13880200802436950 | |
| dc.identifier.uri | https://gcris.yasar.edu.tr/handle/123456789/7443 | |
| dc.identifier.uri | https://doi.org/10.1080/13880200802436950 | |
| dc.language.iso | English | |
| dc.publisher | TAYLOR & FRANCIS INC | |
| dc.relation.ispartof | Pharmaceutical Biology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | PHARMACEUTICAL BIOLOGY | |
| dc.subject | Diabetes mellitus, mushroom, Cerrena unicolor, Coprinus comatus, Lenzites betulina | |
| dc.subject | ACIDIC POLYSACCHARIDE, SUBMERGED CULTURE, TREMELLA-AURANTIA, FRUITING BODIES, STRUCTURAL FEATURES, CORDYCEPS-SINENSIS, GLUCOSE-METABOLISM, MOUSE-LIVER, MUSHROOM, FUNGI | |
| dc.subject | Coprinus Comatus | |
| dc.subject | Diabetes Mellitus | |
| dc.subject | Cerrena Unicolor | |
| dc.subject | Mushroom | |
| dc.subject | Lenzites Betulina | |
| dc.title | Hypoglycemic effect of crude exopolysaccharides produced by Cerrena unicolor- Coprinus comatus- and Lenzites betulina isolates in streptozotocin-induced diabetic rats | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| gdc.author.id | Yamaç, Mustafa/0000-0002-7262-0036 | |
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| gdc.author.wosid | Yamaç, Mustafa/AAF-4420-2019 | |
| gdc.author.wosid | Şentürk, Hakan/F-3092-2011 | |
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| gdc.description.departmenttemp | [Yamac, Mustafa; Bayramoglu, Gokhan; Senturk, Hakan] Eskisehir Osmangazi Univ, Dept Biol, Fac Arts & Sci, TR-26480 Meselik, Eskisehir, Turkey; [Zeytinoglu, Melih] Yasar Univ, Vocat Sch, Izmir, Turkey; [Kanbak, Gungor] Eskisehir Osmangazi Univ, Fac Med, Dept Biochem, TR-26480 Meselik, Eskisehir, Turkey | |
| gdc.description.endpage | 174 | |
| gdc.description.issue | 2 | |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
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| gdc.description.volume | 47 | |
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| person.identifier.orcid | Yamac- Mustafa/0000-0002-7262-0036, | |
| project.funder.name | Eskisehir Osmangazi University Research Foundation [200619016], Scientific Research and Application Center (FBAM), Biology Department of Eskisehir Osmangazi University | |
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