Gökhan Demirkıran2025-10-062019978605011275710.23919/ELECO47770.2019.8990585https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080877500&doi=10.23919%2FELECO47770.2019.8990585&partnerID=40&md5=afceb4af0022bc63b9412ae143366dd6https://gcris.yasar.edu.tr/handle/123456789/9349This study investigates cell fate selection in a single cell by carrying out theoretical analysis on a parametric 2-Dimensional model. The investigated model involves eight fixed parameters and two tuneable parameters r and m where the tuneable parameters are the determinants of cell fate decision. Using these tuneable parameters as the axes the concept of apoptogram where the exact values of r and m pairs that lead to a certain cell fate decision are portrayed as regions is introduced. The boundaries that depicts the regions are theoretically determined in a parametric fashion so that one can construct an apoptogram image given the values of fixed parameters of the model. The regions that correspond to a cell fate decision in the apoptogram provide valuable insights to investigate and manipulate cell fate decisions. Further studies may utilize such concept as a new tool to explore the complexity of cancer and cancer therapy. © 2020 Elsevier B.V. All rights reserved.EnglishCytology, Diseases, Cancer Therapy, Cell Fate Decision, Cell Fates, Single Cells, Tuneable Parameters, CellsCytology, Diseases, Cancer therapy, Cell fate decision, Cell fates, Single cells, Tuneable parameters, CellsConference Object