Yeşim Deniz Özkan-ÖzenJose Arturo Garza-ReyesYigit Kazancoglu2025-10-062024106869671068-69672575-622210.1080/10686967.2024.2394400https://www.scopus.com/inward/record.uri?eid=2-s2.0-85204186685&doi=10.1080%2F10686967.2024.2394400&partnerID=40&md5=dc1a6c77e455f181b71c74624226159ahttps://gcris.yasar.edu.tr/handle/123456789/8277This study integrates the Lean Six Sigma (LSS) DMAIC (design measure analyze improve control) methodology with the Life Cycle and Value Stream Level of RAMI 4.0 by proposing a systematic structure that includes LSS 4.0 tools and techniques for each level. The fuzzy Entropy Weighting method is used to evaluate LSS 4.0 tools and techniques for each level and a sample implementation of the proposed structure is conducted in a high-technology electronics firm. The results indicated that the proposed structure effectively integrates the LSS and DMAIC methodology with the Life Cycle and Value Stream Level of RAMI 4.0. The results suggest that although the DMAIC methodology is applicable for each life cycle stage the most important approaches vary for each life cycle level. Therefore DMAIC implementation for each level should be conducted separately for each life cycle and LSS 4.0 tools and techniques should be chosen according to the specific needs. This article proposes a novel systematic structure that includes LSS 4.0 tools and techniques for each DMAIC stage and that can be used for LSS implementation in RAMI 4.0. The proposed structure will contribute to systemizing the complex structure of Industry 4.0 in the implementation phase of smart factories. © 2024 Elsevier B.V. All rights reserved.EnglishDmaic, Industry 4.0, Lean Six Sigma, Life Cycle And Value Stream, Rami 4.0Article