Cemre CubukcuogluPirouz NourianI. Sevil SariyildizM. Fatih Tasgetiren2025-10-062022092658050926-580510.1016/j.autcon.2021.104102https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124252399&doi=10.1016%2Fj.autcon.2021.104102&partnerID=40&md5=25d0a5326feb62ff2ff771b0b24d2181https://gcris.yasar.edu.tr/handle/123456789/8747The paper proposes a generative design workflow for three major hospital layout planning steps to satisfy multiplex configurational requirements. The initial step is stacking through clustering functional spaces into floor plans for which a spectral method is presented. Subsequently a novel simultaneous process of zoning and routing is proposed as a Mixed-Integer Programming problem-solving task, performed on a quadrilateral mesh whose faces and edges are allocated respectively to the rooms and the corridors. The paper situates the workflow in the context of an Activity-Relations-Chart for a general hospital while demonstrating explaining and justifying the generated optimal floor plans. The conversion of the hospital layout problem to a Mixed-Integer Programming problem enables the use of existing Operations Research solvers allowing for the generation of optimal solutions in a digital design environment. The comprehensive problem formulation for a real-world scenario opens a new avenue for utilization of mathematical programming/optimization in healthcare design. © 2022 Elsevier B.V. All rights reserved.EnglishComputational Design, Corridor Generation, Hospital Design Optimization, Layout Planning, Mixed Integer Programming, Floors, Integer Programming, Operations Research, Optimal Systems, Zoning, Computational Design, Corridor Generation, Design Optimization, Floorplans, Hospital Design Optimization, Integer Programming Problems, Layout Planning, Mixed-integer Programming, Routings, Stackings, HospitalsFloors, Integer programming, Operations research, Optimal systems, Zoning, Computational design, Corridor generation, Design optimization, Floorplans, Hospital design optimization, Integer programming problems, Layout planning, Mixed-Integer Programming, Routings, Stackings, HospitalsArticle