Mustafa YamaçMelih ZeytinoǧluGüngör KanbakGökhan BayramoǧluHakan Şenturk2025-10-06200913880209, 174451161388-02091744-511610.1080/13880200802436950https://www.scopus.com/inward/record.uri?eid=2-s2.0-70749160094&doi=10.1080%2F13880200802436950&partnerID=40&md5=cb951a9eeaf5c81c6cdb9332e9e56745https://gcris.yasar.edu.tr/handle/123456789/10331The objective of this study was to investigate the hypoglycemic activity of crude exopolysaccharides (EPS) produced by three mushroom isolates in streptozotocin-induced diabetic rats. The three experimental groups were fed EPS of Cerrena unicolor (Bull.) Murrill (Polyporaceae) Coprinus comatus (O.F. Mll.) Pers. (Agaricaceae) and Lenzites betulina (L.) Fr. (Polyporaceae) for 7 days. The serum glucose levels significantly decreased after oral administration of EPS by 61.23% with Cerrena unicolor 42.78% with Coprinus comatus and 42.08% with Lenzites betulina. According to histological observations based on staining in pancreatic tissues Langerhans islet areas and cell numbers of diabetic animals increased in response to EPS treatment. In conclusion our findings clearly suggest that exopolysaccharides produced by three mushroom isolates decreased blood glucose levels in STZ-induced diabetic rats. Therefore the studied mushroom exopolysaccharides might be developed as potential oral hypoglycemic agents in the control of diabetes mellitus. This is the first attempted in vivo study using exopolysaccharides of local mushroom isolates for medicinal purpose in Turkey. © 2009 Informa UK Ltd. © 2010 Elsevier B.V. All rights reserved.EnglishCerrena Unicolor, Coprinus Comatus, Diabetes Mellitus, Lenzites Betulina, Mushroom, Glucose, Exopolysaccharide, Glucose, Agaricales, Animal Experiment, Animal Model, Animal Tissue, Article, Cell Count, Cerrena Unicolor, Controlled Study, Coprinus Comatus, Female, Fungus Isolation, Glucose Blood Level, Histology, Hypoglycemia, In Vivo Study, Lenzites Betulina, Mushroom, Nonhuman, Pancreas Cell, Pancreas Islet, Polyporaceae, Rat, Staining, Streptozocin Diabetes, Treatment Response, Turkey (republic), Agaricaceae, Animalia, Basidiomycota, Coprinus Comatus, Rattusexopolysaccharide, glucose, Agaricales, animal experiment, animal model, animal tissue, article, cell count, Cerrena unicolor, controlled study, coprinus comatus, female, fungus isolation, glucose blood level, histology, hypoglycemia, in vivo study, Lenzites betulina, mushroom, nonhuman, pancreas cell, pancreas islet, Polyporaceae, rat, staining, streptozocin diabetes, treatment response, Turkey (republic), Agaricaceae, Animalia, Basidiomycota, Coprinus comatus, RattusArticle