Gökhan DemirkıranGüleser Kalayci DemirCüneyt GüzelişGuzelis, CuneytDemirkiran, GokhanDemir, Guleser Kalayc2025-10-062017978605010737197815386172362-s2.0-85046282876https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046282876&partnerID=40&md5=d5f1d775d8780fa8fd339f007544023ahttps://gcris.yasar.edu.tr/handle/123456789/9670Under gamma irradiation p53 gene regulatory network is able to exhibit three different modes namely low state oscillations and high state. There are experimental studies demonstrating that oscillatory behaviour of p53 is due to the interaction between upstream mediator of p53 i.e. ATM and a negative feedback loop formed by Wipl with that upstream. By proposing a canonical model based on ordinary differential equations made up of polynomial type birth and death terms we show mathematically that the simple interaction between ATM and Wipl is indeed able to exhibit three different behaviours relevant to DNA damage response of p53 network. We further carry out bifurcation analysis on the model with the aim of investigating the mutations such as Wip1 overexpression and ATM deficiency. Based on the proposed canonical model we show that Wipl is an important target for curing these types of mutations. © 2023 Elsevier B.V. All rights reserved.Englishinfo:eu-repo/semantics/closedAccessBifurcation (mathematics), Internet Protocols, Ordinary Differential Equations, 2 - Dimensional, Canonical Models, Dimensional Model, Gamma Irradiation, Gene Regulatory Networks, Model-based Opc, Negative Feedback Loop, Oscillatory Behaviors, P53 Gene, Simple++, IrradiationBifurcation (mathematics), Internet protocols, Ordinary differential equations, 2 - Dimensional, Canonical models, Dimensional model, Gamma irradiation, Gene regulatory networks, Model-based OPC, Negative feedback loop, Oscillatory behaviors, P53 gene, Simple++, IrradiationConference Object