Lei ZhengGonzalo García De PolaviejaVerena WolframMusa Hakan AsyaliRoger C. HardieMikko A. JuusolaWolfram, VPolavieja, GGJuusola, MZheng, LAsyali, MHDe Polavieja, Gonzalo G.Hardie, RC2025-10-06200615407748, 002212950022-12951540-774810.1085/jgp.2005094702-s2.0-33646162888https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646162888&doi=10.1085%2Fjgp.200509470&partnerID=40&md5=cb0701633fd64f267c2d8f384538e9c3https://gcris.yasar.edu.tr/handle/123456789/10386https://doi.org/10.1085/jgp.200509470At the layer of first visual synapses information from photoreceptors is processed and transmitted towards the brain. In fly compound eye output from photoreceptors (R1-R6) that share the same visual field is pooled and transmitted via histaminergic synapses to two classes of interneuron large monopolar cells (LMCs) and amacrine cells (ACs). The interneurons also feed back to photoreceptor terminals via numerous ligand-gated synapses yet the significance of these connections has remained a mystery. We investigated the role of feedback synapses by comparing intracellular responses of photoreceptors and LMCs in wild-type Drosophila and in synaptic mutants to light and current pulses and to naturalistic light stimuli. The recordings were further subjected to rigorous statistical and information-theoretical analysis. We show that the feedback synapses form a negative feedback loop that controls the speed and amplitude of photoreceptor responses and hence the quality of the transmitted signals. These results highlight the benefits of feedback synapses for neural information processing and suggest that similar coding strategies could be used in other nervous systems. © The Rockefeller University Press. © 2008 Elsevier B.V. All rights reserved., MEDLINE® is the source for the MeSH terms of this document.Englishinfo:eu-repo/semantics/openAccessAnimal Experiment, Article, Drosophila, Feedback System, Information, Light, Mutant, Nonhuman, Photoreceptor, Signal Transduction, Statistical Significance, Stimulus, Synapse, Visual System, Wild Type, Animals, Drosophila Melanogaster, Electrophysiology, Evoked Potentials Visual, Feedback, Interneurons, Light, Microelectrodes, Models Biological, Patch-clamp Techniques, Photoreceptors Invertebrate, Signal Transduction, Synaptic Transmission, Temperatureanimal experiment, article, Drosophila, feedback system, information, light, mutant, nonhuman, photoreceptor, signal transduction, statistical significance, stimulus, synapse, visual system, wild type, Animals, Drosophila melanogaster, Electrophysiology, Evoked Potentials Visual, Feedback, Interneurons, Light, Microelectrodes, Models Biological, Patch-Clamp Techniques, Photoreceptors Invertebrate, Signal Transduction, Synaptic Transmission, TemperatureArticle