Bahar H. YalçınkayaSeda GencJale ÇatakMustafa ÖzilgenBayram Yilmaz2025-10-0620189780128095973, 978012814925610.1016/B978-0-12-809597-3.00308-4https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052300252&doi=10.1016%2FB978-0-12-809597-3.00308-4&partnerID=40&md5=fb9dac04674fde48e374476cd4966c8chttps://gcris.yasar.edu.tr/handle/123456789/9577Mitochondria are the "powerhouse" of the cells where more than 90% of the cellular energy is produced. Functions of the body like muscle work performance and signal transmission along the nervous system are achieved by utilizing the energy generated in the mitochondria. The exergy loss of energy production ability of the mitochondria causes problems in the cellular repair and renewal processes. Aging is one of the major causes for the loss of the energy efficiency of mitochondria. There are numerous diseases related with the mismanagement or failure of the energy generation by the mitochondria in corresponding cells. © 2018 Elsevier B.V. All rights reserved.EnglishAging, Cancer Alzheimer's Disease, Cellular Energy Management, Diabetes, Energy Metabolism, MitochondriaBook Part