The effects of the duration of formal education on adult brain: A voxel-based morphometry (diffeomorphic anatomical registration using exponentiated lie algebra) DARTEL Study
| dc.contributor.author | EROL OZAN | |
| dc.contributor.author | Ali Saffet GÖNÜL | |
| dc.contributor.author | Özlem Donat EKER | |
| dc.contributor.author | Orhan DEMİREL | |
| dc.contributor.author | Çağdaş EKER | |
| dc.contributor.author | Ömer Kitiş | |
| dc.date.accessioned | 2025-10-22T16:06:47Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Amaç: Son dönemde yapılan çalışmalar çevresel uyaranların sürekli verilmesinin beyinde yapısal değişikleri tetikleyebileceğini göstermiştir. Okul eğitimi sırasında insan beyni sadece yeni bilgiler ile karşılaşmamakta eski bilgilerini de çağırarak yenileri ile birleştirmektedir. Biz bu çalışmada yoğun öğrenme sürecinin yaşandığı okulda geçirilen sürenin beyin üzerindeki etkisini voksel tabanlı morfometri (VBTM)DARTEL yöntemini kullanarak araştırmayı amaçladık.Yöntem: Bu çalışmaya 47 sağlıklı erişkin dahil edildi. SCID-NP ile taranan hastaların daha sonra 1.5 T gücündeki Siemens Manyetik Rezonans Görüntüleme cihazı ile beyin görüntüleri alındı. T1 ağırlıklı görüntüler SPM 5te (Statistical Parametric Mapping software) VBTM protokolü kullanılarak değerlendirildi.Bulgular: VBTM değerlendirmesi sonucunda sağ ön hipokampus hacminin eğitim ile korele olduğu tespit edildi. Bilateral oksipital loblarda (BA 18) ve sağ serebullum da eğitim süresinin artmasına paralel gri madde artışı tespit edildi. Sağ parietal korteks (BA 7) ve sağ orta frontal kortekste (BA 8) ise gri madde miktarı eğitim süresi ile negatif korelasyon göstermekteydi.Sonuçlar: Bu çalışmanın sonuçları beyinin yeni uyaranın tespiti semantik ve uzay bellek ve görsel sistemler ile ilgili alanlardaki gri madde hacmi ile okulda geçirilen süre arasında ilişki olduğunu göstermiştir. Bu ilişki ilgili alanlarının yoğun uyarımı ile ilişkili olabilir. | |
| dc.identifier.citation | 1. Coffey CE Saxton JA Ratcliff G Bryan RN Lucke JF. Relation of education to brain size in normal aging: implications for the reserve hypothesis. Neurology 1999,53:189-196.2. Draganski B Gaser C Kempermann G Kuhn HG Winkler J Buchel C et al. Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci 2006,26:6314-6317.3. Ilg R Wohlschlager AM Gaser C Liebau Y Dauner R Woller A et al. Gray matter increase induced by practice correlates with taskspecific activation: a combined functional and morphometric magnetic resonance imaging study. J Neurosci 2008,28:4210-4215.4. Staff RT Murray AD Deary IJ Whalley LJ. What provides cerebral reserve? Brain 2004,127:1191-1199.5. Brown J Cooper-Kuhn CM Kempermann G Van Praag H Winkler J Gage FH et al. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 2003,17:2042-2046.6. Draganski B Gaser C Busch V Schuierer G Bogdahn U May A. Neuroplasticity: changes in grey matter induced by training. Nature 2004,427:311-312.7. Bennett DA Wilson RS Schneider JA Evans DA Mendes de Leon CF Arnold SE et al. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology 2003,60:1909-1915.8. Ashburner J Friston KJ. Voxel-based morphometry--the methods. Neuroimage 2000,11:805-821.9. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007,38:95-113.10. Kandel E.R. KI Iversen S. Learning and Memory In: Kandel E.R. SJH Jessell T.M. editor. Principles of Neural Science Fourth Edition ed: McGraw-Hill Co. 2000. p. 1227-1246.11. Kullmann DM Lamsa KP. Long-term synaptic plasticity in hippocampal interneurons. Nat Rev Neurosci 2007,8(9):687-99.12. Eriksson PS Perfilieva E Bjork-Eriksson T Alborn AM Nordborg C Peterson DA et al. Neurogenesis in the adult human hippocampus. Nat Med 1998,4:1313-1317.13. Kempermann G Kuhn HG Winkler J Gage FH. [New nerve cells for the adult brain. Adult neurogenesis and stem cell concepts in neurologic research]. Nervenarzt 1998,69:851-857.14. Gage FH. Neurogenesis in the adult brain. J Neurosci 2002,22:612-613.15. Lepage M Habib R Tulving E. Hippocampal PET activations of memory encoding and retrieval: the HIPER model. Hippocampus 1998,8:313-322.16. Strange BA Dolan RJ. Adaptive anterior hippocampal responses to oddball stimuli. Hippocampus 2001,11:690-698.17. Maguire EA Frith CD Burgess N Donnett JG O'Keefe J. Knowing where things are parahippocampal involvement in encoding object locations in virtual large-scale space. J Cogn Neurosci 1998,10:61-76.18. Burgess N Maguire EA O'Keefe J. The human hippocampus and spatial and episodic memory. Neuron 2002,35:625-641.19. Iaria G Petrides M Dagher A Pike B Bohbot VD. Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice. J Neurosci 2003,23:5945-5952.20. Gron G Wunderlich AP Spitzer M Tomczak R Riepe MW. Brain activation during human navigation: gender-different neural networks as substrate of performance. Nat Neurosci 2000,3:404-408.21. Maguire EA Woollett K Spiers HJ. London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis. Hippocampus 2006,16:1091-1101.22. Kumaran D Maguire EA. The human hippocampus: cognitive maps or relational memory? J Neurosci 2005,25:7254-7259.23. Wolbers T Buchel C. Dissociable retrosplenial and hippocampal contributions to successful formation of survey representations. J Neurosci 2005,25:3333-3340.24. Halligan PW Fink GR Marshall JC Vallar G. Spatial cognition: evidence from visual neglect. Trends Cogn Sci 2003,7:125-133.25. Galati G Committeri G Sanes JN Pizzamiglio L. Spatial coding of visual and somatic sensory information in body-centred coordinates. Eur J Neurosci 2001,14:737-746.26. Moscovitch M Nadel L Winocur G Gilboa A Rosenbaum RS. The cognitive neuroscience of remote episodic semantic and spatial memory. Curr Opin Neurobiol 2006,16:179-190.27. Springer MV McIntosh AR Winocur G Grady CL. The relation between brain activity during memory tasks and years of education in young and older adults. Neuropsychology 2005,19:181-192.28. Miyashita Y. Cognitive memory: cellular and network machineries and their top-down control. Science 2004,306:435-440.29. Bonnet MC Dilharreguy B Allard M Deloire MS Petry KG Brochet B. Differential cerebellar and cortical involvement according to various attentional load: Role of educational level. Hum Brain Mapp 2009,30:1133-1143.30. Frangou S Chitins X Williams SC. Mapping IQ and gray matter density in healthy young people. Neuroimage 2004,23:800-805.31. Haier RJ Jung RE Yeo RA Head K Alkire MT. Structural brain variation and general intelligence. Neuroimage 2004,23:425-433. | |
| dc.identifier.issn | 1017-7833 | |
| dc.identifier.issn | 1302-9657 | |
| dc.identifier.uri | https://gcris.yasar.edu.tr/handle/123456789/11269 | |
| dc.language.iso | Türkçe | |
| dc.source | Klinik Psikofarmakoloji Bülteni | |
| dc.subject | Biyoloji-Eğitim- Eğitim Araştırmaları-Nörolojik Bilimler | |
| dc.title | The effects of the duration of formal education on adult brain: A voxel-based morphometry (diffeomorphic anatomical registration using exponentiated lie algebra) DARTEL Study | |
| dc.type | Article | |
| dc.type | Article | |
| dspace.entity.type | Publication | |
| gdc.coar.type | text::journal::journal article | |
| gdc.index.type | TR-Dizin | |
| oaire.citation.endPage | 226 | |
| oaire.citation.startPage | 221 | |
| publicationissue.issueNumber | 3 | |
| publicationvolume.volumeNumber | 19 | |
| relation.isOrgUnitOfPublication | ac5ddece-c76d-476d-ab30-e4d3029dee37 | |
| relation.isOrgUnitOfPublication.latestForDiscovery | ac5ddece-c76d-476d-ab30-e4d3029dee37 |